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KMID : 0615720150320020077
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 2 p.77 ~ p.85
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The Effects of Sophorae Radix Pharmacopuncture Therapy on the Chunchu(ST25) for DSS-induced Colitis in Rats
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Yang Tae-Jun
Kim Kyeong-Ok
Kim Kyeong-Soo
Park Soo-Yeon
Yang Seung-Joung
Choi Chang-Won
Wei Tung-Shuen
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Abstract
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Objectives: The purpose of this study is to investigate the effects of Sophorae radix pharmacopuncture(SRP) therapy on the Chunchu(ST25) on intestinal disease in rats with dextran sulfate sodium(DSS)-induced colitis.
Methods: The experimental model of colitis was induced by an infection of DSS for fifteen days. After colitis was induced, SRP therapy was practiced on the Chunchu(ST25) once every three days for a total of five times. Afterward, colon length, damage to the colonic mucosa, complete blood count, aspartate aminotransferase(AST), alanine transferase(ALT), blood urea nitrogen(BUN), creatinine, TNF-α and IL-6 were measured.
Results:
The results were obtained as below.
1.Colon length was significantly increased in the SRP group 2 compared to the control group.
2.Damage of colonic mucosa was observed less in the SRP groups than in the other groups.
3.The mean rates of white blood cell(WBC), neutrophils and lymphocytes were significantly increased in SRP group 2 compared to the control group.
4.The mean rates of HGB and hematocrit(HCT) were significantly increased in the SRP compared to the control group.
5.No significant differences were shown in AST, ALT, BUN and Creatinine between the SRP groups and the control group.
6.The mean rate of TNF-α was significantly decreased in the SRP groups compared to the control group.
7.The mean of IL-6 was significantly decreased in the SRP groups compared to the control group.
Conclusions: These results indicated that SRP therapy on Chunchu(ST25) functions as a treatment to the dextran sulfate sodium-induced colitis.
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KEYWORD
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Sophorae radix pharmacopuncture, Dextran sulfate sodium, Colitis, Chunchu(ST25)
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